Background Information
A useful carbon-carbon bond-forming reaction is known as the Aldol Reaction or Aldol Condensation. It is an example of electrophilic substitution at the alpha carbon in enols or enolate anions. Traditionally, it is the acid- or base-catalyzed condensation of one carbonyl compounds with the enolate/enol of another, which may or may not be the same, to generate a β-hydroxy carbonyl compound—an aldol. It is reversible in nature. The reaction may occur between two molecules of aldehyde, two molecules of ketones or one molecule of aldehyde and a molecule of ketone. When two different carbonyl compounds react, it is known as mixed aldol/ Crossed aldol condensation.
Reactions in which a larger molecule is formed from smaller components with the elimination of a very small by-product such as water are termed Condensations. Hence the following examples are properly referred to as aldol condensations. The dehydration step of an aldol condensation is also reversible in the presence of acid and base catalysts. Consequently, on heating with aqueous solutions of strong acids or bases, many α, β-unsaturated carbonyl compounds fragment into smaller aldehyde or ketones, a process known as the retro-aldol reaction. Below, a few examples of aldol condensation reaction are:
The product has both a carbonyl and an alcohol group; since the chemistry was initially developed with aldehydes the name "Ald-ol" (aldehyde-alcohol) was coined and has been applied to the reaction that forms it. For aldol condensation, the presence of α-H (acidic hydrogen atom) atom is necessary. In the absence of α-H atom, it can undergo the Cannizaro reaction. Aldol condensation involves the following steps in the mechanism:
1. Addition phase:
(a) Formation of an enol or enolate anion.
(b) Nucleophilic addition
(c) Proton transfer
2. Dehydration phase (If strong base/acid or some heat is applied)
Using acetone as an example:
Step 1: An acid-base reaction occurs first. Ethoxide functions as a base and removes the acidic -hydrogen giving the reactive enolate.
Step 2: The nucleophilic enolate attacks another molecule of acetone at the electrophilic carbonyl C in a
nucleophilic addition type process giving an intermediate alkoxide.
Step 3: An acid-base reaction. The alkoxide deprotonates a solvent molecule (here ethanol) creating hydroxide and the
ββ size 12{β} {}hydroxyaldehydes or aldol product is formed.
There is little difference mechanistically between an acid or base catalyzed mechanism but examples of both have been given for completeness.
In next figure, the actual carbon-carbon bond formation has shown in different color for simplicity.
Acid catalyzed reaction mechanism:
Base catalyzed reaction mechanism:
From the mechanism it is clear that presence of electron withdrawing group in acceptor molecule facilitates the reaction and vice versa.
Some Important Facts:
1. The reaction involves an enolate reacting with another molecule of the aldehyde.
2. Remember enolates are good nucleophiles and carbonyl C is electrophiles.
3. The products of these reactions are
ββ size 12{β} {}hydroxyaldehydes or aldehyde-alcohols = aldols.
4. The simplest aldol reaction is the condensation of ethanal.
Question: Why isn't the simplest example of an Aldol the condensation of methanal?
To recap, Aldol condensation depends mainly on two factors:
- Acidity of α-H atom (hydrogen atom present next to carbonyl center)
- Reactivity of carbonyl compounds
Here is an example to explain the above facts:
In methyl cyclohexanone two different types of acidic proton is present next to carbonyl center. Due to steric and electronic reasons, one proton is more acidic than the other; whereas benzaldehyde doesn’t have any acidic proton. This is an example of Crossed aldol condensation. Depending on the position of hydroxyl group you can get a mixture of diastereomeric products. The dehydration step of an aldol condensation is also reversible in the presence of acid and base catalysts. Consequently, on heating with aqueous solutions of strong acids or bases, many α, β-unsaturated carbonyl compounds fragment into smaller aldehyde or ketones, a process known as the retro-aldol reaction.
The condensation is usually pushed to completion by dehydration; in some contexts the dehydration may be assumed to be part of the aldol condensation itself.The base-induced elimination is normally not seen with alcohols other than with aldols. This reaction probably proceeds via formation of an enolate, followed by loss of water molecule; formation of the, ß-unsaturated ketone makes up for the poor leaving group ability of hydroxide. (Of course, with acid catalysis the dehydration follows the normal protonation/loss of water/loss of proton mechanism.) Either acid- or base-catalyzed dehydration is helped by increased temperature.
Several observations are necessary at this point.
1. All of the reactions shown above are reversible. You should be able, on your own to predict where each of the equilibria shown above should lie (is K > 1 or is K < 1?) 2. You should be able to predict how changes in structure will change the position of the equilibrium. (Examples: more or less bulky R groups in the ketone; ketones vs. aldehydes; electronic effects for electron-donating and electron-withdrawing groups.) 3. You should notice that the outcome of a mixture of carbonyl compounds depends on their structure: if there is no proton, no enolate can form and a cross-aldol condensation is possible. If both can form enolates, and both carbonyl groups are of similar reactivity, mixtures of products will result.
In this lab condensation between acetophenone and 4-nitrobenzaldehyde will take place. The reaction scheme as follows:
“Green Chemistry” is important from an environmental point of view. It requires fewer amounts of solvent and chemicals thought to be harmful to the environment. Though there are some possible drawbacks like (a) Low yield, (b) Slow reaction and (c) Increase in reaction cost, still we need to endeavor to keep our environment clean.
Exercise 1 Enter the letter of any compound that does not meet the structural requirements for the aldol condensation:
Answer: C, F etc……. (Convince yourself)
Exercise 2 Write the letter of any
ββ size 12{β} {}-hydroxyaldehyde or
ββ size 12{β} {}- hydroxyketone?
Answer: B, D etc…….. (Convince yourself)
Exercise 3 Each of the following compounds was prepared by an aldol condensation followed by dehydration. In each case, select the structure of the starting material from the list of choices in the box below.
Answer: (a) FF (b) BB (c) __? __ (Convince yourself)
Exercise 4 Each of the following compounds was prepared by a crossed aldol condensation followed by dehydration. In each case, select the structures of the starting materials from the list of choices in the box above. Enter the letter of the compound that serves as the nucleophilic component followed by that of the electrophilic component. For example, the nucleophilic component used to prepare the first compound is A, while the electrophilic component is F.
Answers: (a) AF (b)